The project “Trusted Ecosystem of Applied Medical Data eXchange (TEAM-X)” explores and implements solutions that enable future healthcare to overcome and implement sectoral and domain boundaries. The goal is to establish a protected and trusted digital data ecosystem based on the Gaia-X infrastructure for the development of data-driven business models, products, and services as a basis for future-oriented healthcare. Data is used to improve prevention, predication, personalization, and participation in care. Health data that is currently not accessible at all or only with difficulty will be made available and usable in the future. Patients will have data sovereignty and determine who has access to this highly sensitive data and to what extent. The data will be stored in encrypted form and its use will be fully documented. Access will be possible from any end device and data will be released for research purposes.